Our Technology

Novel Method for Rapid Detection of Contaminated Cough Syrup Using TD-NMR

• Demonstrated that WaveGuide’s Formµla™ μNMR can distinguish between many different cough syrups.
• Showed that WaveGuide’s Formµla™ μNMR can detect contaminants such as Diethylene glycol and Ethylene glycol as low as 2.5% concentration.
• Illustrated how an inexpensive, battery operated, portable TD-NMR system is an easy way to hit many touch points to protect the supply chain.

Rapid detection of Tuberculosis (TB) in Clinical Samples Using WaveGuide Separation Assay and μNMR Formµla™ prototype.

Initial proof of concept studies with polyclonal antibodies displayed:

• Ability to detect clinically relevant strains of M. tuberculosis in Sputum.
• The  WaveGuide Formμla™ μNMR detected 10⁴ CFU/mL and should improve with further testing.
• Successfully verified technology using clinical sputum samples.
• An overall accuracy of ~90%, and sample accuracy ~85%.
• Successful detection of TB between 1-3 hrs in sputum
• Larger data sets are needed for further evaluation. It is expected that using monoclonal antibodies will increase both detection limits and accuracy. Further studies with this instrument are warranted.

Rapid detection of falsified or substandard vaccines using portable battery-operated TD-NMR.

• The WaveGuide μNMR can be successfully used for the rapid detection of falsified and substandard vaccines.
• The novel system can distinguish authentic vaccines from surrogate solutions, diluted originals, verified vaccines from various manufacturers,
  and in some cases distinguish across different storage conditions.
• Such analysis can be exploited for other types of biopharma assets as well as consumer products, forensics, and supply chain integrity.

Breakthrough Portable NMR Platform for Quantitative Analysis & Screening Complementing Optical Methods and a Logical Alternative to HPLC Methods in BioPharma.

• The WaveGuide μNMR authenticated pharmaceutical and consumer products (i.e., mAbs, vaccines, hyaluronic acid), Raw Materials, API’s, Final Product Confirmation, Stability studies, and accelerated storage conditions for product degradation.

Portable Time-Domain NMR: A rapid method for detecting changes in complex pharmaceutical materials and formulations.

• The evaluation of time-domain NMR to detect differences between pharmaceutical materials was performed and demonstrated excellent discrimination capability for use in antibody identification using an innovative portable instrument.
• For small molecule applications, TD-NMR can detect if solvents are received neat or tainted with moisture, impurities, or denaturants.
• The results presented demonstrate a preliminary evaluation of TD-NMR for testing applications relevant to the manufacture of antibody
  pharmaceuticals.

Analysis of Biopharmaceutical Formulations by Time Domain Nuclear Magnetic Resonance (TD-NMR) Spectroscopy: A Potential Method for Detection of Counterfeit Biologic Pharmaceuticals.

• The WaveGuide Formμla™ μNMR can determine the differences between native proteins and biosimilars at the same concentration and formulation.
• The measurement using TD-NMR is a quantitative method that can detect variations in concentration of antibodies that are less than 2 mg/mL.well below the concentration of most antibody formulations.

NMR in the palm of your hand.

• An analysis of PD-1, PD-L1 inhibitors and multi valent vaccines using the WaveGuide μNMR was performed, with the ability to identify authentic, diluted and biosimilar compounds from each other.

Forensic analysis of biological agents and consumer products.

• WaveGuide’s portable µNMR has shown the ability to distinguish biosimilars when analyzing immuno-oncology agents PD-1 and PD-L1 inhibitors as well as the differentiation of Hyaluronic Acid (HA) concentrations from Silicone oil in dermal fillers.

Tool for monitoring viscosity content and brand authentication of petroleum products.

• The WaveGuide μNMR was used to analyze petroleum products including motor oils and diesel fuel with little or no sample preparation in a
  nondestructive and noninvasive method.
• The WaveGuide uNMR, allows field analysis and can be performed to determine the viscosity and authenticity of branded petroleum products.